ChromoHub: a data hub for navigators of chromatin-mediated signalling


Genes involved in chromatin-mediated signalling constitute emerging target classes for future therapies. Here, we map on phylogenetic trees information published by the scientific community on the therapeutic relevance, the biology, the structure of these genes, and related chemical inhibitors.

If you find this resource helpful in your research, thank you for citing the following article:
Liu L, Zhen XT, Denton E, Marsden BD, Schapira M., Bioinformatics (2012): ChromoHub: a data hub for navigators of chromatin-mediated signalling [pubmed]



Tree Type

Target Class
  Preview options for all classes (may be slow)

Chemical Modification of Proteins

Writers
KAT: Acetylate lysines PARP: ADP-ribosylate proteins
PMT: Methylate lysines
Readers
BAH: Read methyl-lysines BROMO: Read acetyl-lysines CW: methyl-lysine reader CHROMO: Read methyl-lysines MACRO: bind ADP-ribosylated proteins
MBT: Read methyl-lysines PHD: Read methyl-lysines, acetylated lysines, methyl-arginines, unmodified lysines PWWP: Read methyl-lysines, bind DNA SPINDLIN: methyl-lysine/arginine reader TUDOR: Read methyl-lysines, methyl-arginines YEATS: read acetyl-lysines and crotonyl-lysines
Erasers
HDAC: Deacetylate lysines KDM: De-methylate lysines
PADI: Deiminate arginines

Chemical Modification of DNA

Writers
DNMT: Methylate CpG dinucleotides
Readers
CXXC: Bind to nonmethyl-CpG dinucleotides MBD: Bind to methyl-CpG dinucleotides
Erasers
TET: DNA hydroxylases. Participate in DNA de-methylation

Chemical Modification of RNA

Writers
RNMT: Methylate RNA Pseudouridine synthases: catalyze the site-specific isomerization of uridines on RNA
Readers
YTH: bind to methylated RNA
Erasers

Chromatin Remodelling

Helicases: Involved in chromatin remodeling SANT: Involved in chromatin remodeling

Histones

Histone

WDR

WDR: Versatile binding module
Click thumbnail above or search for a gene (or comma-separated gene list):


Options
Disease Associations
Summary
Inhibitors
     Chemical Probes

Browse inhibitors or visit ChEpiMod
Ligands in Structures

structure identity cut-off:
Substrate
Search Gene
Domain Architecture

SGC Antibodies:
Antigen Produced
FAb Produced
IgG Produced


Cancer Genomics:
Expression in Cancer Lines

Only show cell lines which have mRNA expression data from:
Gene Fusions in Cancer